25 May 2020 Salinomycin-loaded PLA nanoparticles: drug quantification by GPC and wave voltammetry and biological studies on osteosarcoma cancer stem
IC50 Value:; Target: Antibacterial; Anticancer; Salinomycin, a polyether ionophore antibiotic isolated from Streptomyces albus, has been shown to kill CSCs in different types of human cancers, most likely by interfering with ABC drug transporters, the Wnt/?-catenin signaling pathway, and other CSC pathways[1].; in vitro: Salinomycin acts as a potassium ionophore and thereby interferes with
Salinomycin sodium (SAL‐Na) is active against certain Gram‐positive bacteria, while Gram‐negative species are resistant. SAL‐Na at the proposed concentration is unlikely to increase shedding of Salmonella, Escherichia coli and Campylobacter and or induce resistance and cross‐resistance to antimicrobials important in human and animal Unfortunately Salinomycin sodium salt (Cat. No. 3637) has been withdrawn from sale for commercial reasons. Salinomycin, a polyether antibiotic produced by Streptomyces albus, is widely used in animal husbandry as an anticoccidial drug and growth promoter. Situated within the salinomycin biosynthetic gene cluster, slnR encodes a LAL-family transcriptional regulator.
Salinomycin has a high affinity for monovalent cations, particularly potassium. Salinomycin is used to control coccidia in animals and for growth promotion in ruminants. Salinomycin sodium (SAL‐Na) is active against certain Gram‐positive bacteria, while Gram‐negative species are resistant. SAL‐Na at the proposed concentration is unlikely to increase shedding of Salmonella, Escherichia coli and Campylobacter and or induce resistance and cross‐resistance to antimicrobials important in human and animal Unfortunately Salinomycin sodium salt (Cat. No. 3637) has been withdrawn from sale for commercial reasons. Salinomycin, a polyether antibiotic produced by Streptomyces albus, is widely used in animal husbandry as an anticoccidial drug and growth promoter.
MOL SDF PDB SMILES InChI. Similar Structures.
Salinomycin Sodium (syn: Coxistal, Coxistac) is the sodium salt of Salinomycin, a carboxylic polyether ionophore isolated from Streptomyces albus that has been widely used as an agricultural antibiotic to prevent coccidiosis in poultry. Salinomycin was first isolated in 1974 by the research division of Kaken Chemical Co. in Tokyo Japan.
However, its biosynthesis had only been studied by feeding experiments with isotope-labeled precursors. Salinomycin (SAL), a broad spectrum antibiotic and a coccidiostat has been found to counter tumour resistance and kill cancer stem cells with better efficacy than the existing chemotherapeutic agents; paclitaxel and doxorubicin. This refocused its importance for treatment of human cancers.
16 May 2017 Salinomycin kills cancer stem cells by sequestering iron in lysosomes · Abstract. Cancer stem cells (CSCs) represent a subset of cells within
Salinomycin (SAL), a broad spectrum antibiotic and a coccidiostat has been found to counter tumour resistance and kill cancer stem cells with better efficacy than the existing chemotherapeutic agents; paclitaxel and doxorubicin. This refocused its importance for treatment of human cancers.
In cases of higher mortality, histopathology of skeletal muscles showed severe muscle degeneration and necrosis with myocardial fragmentation, oedema and fat infiltration, suggesting cardiac failure is probably related to animal death. I dag · Salinomycin Premix Market Forecast to 2025 – Driven by Industry Major Players, Dynamics, Future Opportunities, Revenue, Growth By [email protected] on April 16, 2021 Detailed Study on the Global Salinomycin Premix Market
This International Standard specifies a high-performance liquid chromatographic (HPLC) method for the determination of the monensin, narasin and salinomycin contents of animal feeding stuffs, supplements (dry and liquid) and mineral premixtures. The method is not applicable to drug premixes (pharmaceutical products). Salinomycin is as an antimicrobial and anticoccidial antibiotic. In 2009, a groundbreaking result was published in the scientific journal Cell (Ref), showing that Salinomycin can be effective in killing the cancer stem cells (CSC), the cancer cell population that is responsible for chemo resistance and metastasis. Salinomycin is widely used in animal husbandry as a food additive due to its antibacterial and anticoccidial activities.
Swish företag logga in
No. 3637) has been withdrawn from sale for commercial reasons. Salinomycin, a polyether antibiotic produced by Streptomyces albus, is widely used in animal husbandry as an anticoccidial drug and growth promoter. Situated within the salinomycin biosynthetic gene cluster, slnR encodes a LAL-family transcriptional regulator.
Cell Data
Salinomycin (Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic agent. action of salinomycin. Salinomycin shows cyto- toxic effect by disrupting the balance of sodium and potas- sium ions across the cell membrane and the
Visit ChemicalBook To find more Salinomycin(53003-10-4) information like chemical properties,Structure,melting point,boiling point,density,molecular formula
“To investigate its action, we developed a surrogate salinomycin drug, ironomycin, that was at least 10-fold more potent than salinomycin against CSCs in vitro and
Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Salinomycin (Procoxacin)，一种钾离子载体抗生素，选择性抑制革兰氏阳性菌的 生长(gram-positive bacteria)。Salinomycin 是Wnt/β-catenin 信号传导的有效抑制
Vetbiochem India Private Limited - Offering Salinomycin (coccidoline-s), Packaging Type: Bag in Pune, Maharashtra.
Seb student
2019-05-27 · Salinomycin is a powerful cancer treatment. It is an antibiotic that’s been used to treat infections in poultry, but despite its demonstrated ability to cure human diseases like cancer and malaria, it is rarely used in humans because it would negate the need for conventional treatments like chemotherapy, radiation, and surgery.
Biosynthesis Salinomycin är en fodertillsats av gruppen koccidiostatika som ämnen avsedda att döda eller hindra tillväxten av parasitiska protozoer (encelliga organismer). Salinomycin in är endast tillåtet i vissa fjäderfäfoder och kan vara skadligt för andra djurslag. Salinomycin is an ionophore, also marketed as a coccidiostat, which is related more closely to monensin than is lasalocid. The ionic affinity of salinomycin is predominantly to sodium and potassium ions, and its mode of action and cellular effects are similar to those of monensin.87. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Salinomycin (71; R = H), obtained by culturing a strain of Streptomyces albus 〈72JAP(K)7225392〉, and narasin (71; R = Me), 4-(S)-methylsalinomycin, the main component of a polyether complex produced by Streptomyces aurofaciens 〈78JAN1〉 are now used to prevent coccidiosis, particularly in broiler chickens. Salinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug.
2017-03-28 · Salinomycin is a potent inhibitor of P-gp, which makes cells sensitive to chemotherapeutic drugs. 10 Salinomycin exhibits antibacterial activity, especially against Gram-positive bacteria, including various antibiotic-resistant species of Streptomyces.
Salinomycin (SAL), a broad spectrum antibiotic and a coccidiostat has been found to counter tumour resistance and kill cancer stem cells with better efficacy than the existing chemotherapeutic agents; paclitaxel and doxorubicin. This refocused its importance for treatment of human cancers. Salinomycin is an ionophore, also marketed as a coccidiostat, which is related more closely to monensin than is lasalocid. The ionic affinity of salinomycin is predominantly to sodium and potassium ions, and its mode of action and cellular effects are similar to those of monensin.87. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Salinomycin is as an antimicrobial and anticoccidial antibiotic. In 2009, a groundbreaking result was published in the scientific journal Cell (Ref), showing that Salinomycin can be effective in killing the cancer stem cells (CSC), the cancer cell population that is … Histopathologically, salinomycin induces severe myocardial and skeletal muscle lesions showing myocardial hyperemia, myocardial fiber degeneration and myocardial mitochondria damage.
The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. 2 hours ago salinomycin/kg salinomycin sodium. — ≤ 10 g 20- desoxysalinomycin/kg salinomycin sodium.